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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	thoracic aortic aneurysm
ICD-0-3	NA
Methods	qPCR, Western blot, etc.
Sample	TAA tissues,
Expression Pattern	up-regulated
Function Description	LOXL1-AS was upregulated in TAA patients than in healthy controls in aortic media specimens. Altered expression levels of LOXL1-AS distinguished TAA patients from healthy controls. LncRNA Giver was also upregulated in TAA patients than in healthy controls in aortic media specimens, and was positively correlated with LOXL1-AS. LOXL1-AS overexpression mediated the upregulation of Giver in human aortic smooth muscle cells (HAOSMC), while Giver overexpression failed to significantly affect LOXL1- AS. LOXL1-AS and Giver overexpression resulted in promoted proliferation and inhibited apoptosis of HAOSMC. Giver silencing played an opposite role and attenuated the effect of LOXL1-AS overexpression. Therefore, LOXL1-AS was upregulated in TAA and regulated proliferation and apoptosis of LOXL1-AS by upregulating Giver.
Pubmed ID	31471532
Year	2019
Title	LncRNA LOXL1-AS is upregulated in thoracic aortic aneurysm and regulated proliferation and apoptosis of aortic smooth muscle cells

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