Basic Information
| LncRNA/CircRNA Name | LOXL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:73908071-73928248 |
| Ensemble | ENSG00000261801 |
| Refseq | NR_040066 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | medulloblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | medulloblastoma tissues, cell lines(Daoy, D283, D425, D341, D458) |
| Expression Pattern | up-regulated |
| Function Description | It was initially found that LOXL1-AS1 was significantly overexpressed in clinical medulloblastoma tissues compared with the adjacent noncancerous tissues. Cell cycle arrest led to eventual cell apoptosis by LOXL1-AS1 knockdown. knockdown of LOXL1-AS1 inhibited cell migration and reversed epithelial-to-mesenchymal transition (EMT). |
| Pubmed ID | 30050750 |
| Year | 2018 |
| Title | LncRNA LOXL1-AS1 Promotes the Proliferation and Metastasis of Medulloblastoma by Activating the PI3K/AKT Pathway. |
External Links
| Links for LOXL1-AS1 | GenBank HGNC NONCODE |
| Links for medulloblastoma | OMIM COSMIC |