Basic Information
| LncRNA/CircRNA Name | LOXL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:73908071-73928248 |
| Ensemble | ENSG00000261801 |
| Refseq | NR_040066 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | gastric cancer tissues, gastric cancer cell lines (MKN-45, AGS, SGC7901 and MGC-803) and human normal gastric epithelial cell line GES-1 |
| Expression Pattern | up-regulated |
| Function Description | LOXL1 AS1 was highly expressed in tissues and cells of gastric cancer. The upregulation of LOXL1 AS1 predicted poor prognosis in gastric carcinoma. Our find ings demonstrated that LOXL1 AS1 accelerated the deterioration of gastric cancer by inducing cell proliferation, migration, EMT and stemness. Moreover, the expression of USF1 in gastric cancer was higher than in normal control and LOXL1 AS1 negatively modulated USF1. Functionally, LOXL1 AS1 acted as a ceRNA to upregulate USF1 via sponging miR 708 5p. Besides, we confirmed USF1 promoted the transcription of stemness marker SOX2. Rescue experiments testified the stimulative role of LOXL1 AS1/miR 708 5p/USF1 pathway in gastric cancer progression. It was also validated that LOXL1 AS1 facilitated cell growth of gastric carcinoma in vivo. |
| Pubmed ID | 31468594 |
| Year | 2019 |
| Title | LncRNA LOXL1-AS1 facilitates the tumorigenesis and stemness of gastric carcinoma via regulation of miR-708-5p/USF1 pathway |
External Links
| Links for LOXL1-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |