Basic Information
| LncRNA/CircRNA Name | LRB1 |
| Synonyms | uc007biz.1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR |
| Sample | hepatocellular carcinoma serum |
| Expression Pattern | up-regulated |
| Function Description | The results indicated that the serum LRB1 levels in patients with HCC were significantly increased compared with healthy volunteers. The serum LRB1 levels were positively associated with ?-fetoprotein (AFP) expression, large tumor sizes, tumor stage (tumor-node metastasis or Barcelona Clinic Liver Cancer stage) and venous invasion, and were negatively associated with overall survival. Additionally, the use of a combination of LRB1, AFP and des-?-carboxy prothrombin (DCP) markers for the diagnosis of HCC, the diagnostic accuracy was increased compared with using LRB1 alone. |
| Pubmed ID | 30008842 |
| Year | 2018 |
| Title | Serum Long Noncoding RNA LRB1 as a Potential Biomarker for Predicting the Diagnosis and Prognosis of Human Hepatocellular Carcinoma |
External Links
| Links for LRB1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |