Basic Information
| LncRNA/CircRNA Name | LRB1 |
| Synonyms | light-response BTB 1,T3F17.9 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR ect. |
| Sample | the tumor tissues, peripheral blood of the HCC patients, a second blood sample was obtained 10 days after surgery |
| Expression Pattern | up-regulated |
| Function Description | the serum LRB1 levels in patients with HCC were significantly increased compared with healthy volunteers. The serum LRB1 levels were positively associated with a-fetoprotein (AFP) expression, large tumor sizes, tumor stage (tumor-node metastasis or Barcelona Clinic Liver Cancer stage) and venous invasion, and were negatively associated with overall survival. Additionally, the use of a combination of LRB1, AFP and des-r-carboxy prothrombin (DCP) markers for the diagnosis of HCC, the diagnostic accuracy was increased compared with using LRB1 alone. |
| Pubmed ID | 30008842 |
| Year | 2018 |
| Title | Serum long noncoding RNA LRB1 as a potential biomarker for predicting the diagnosis and prognosis of human hepatocellular carcinoma. |
External Links
| Links for LRB1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |