Basic Information
| LncRNA/CircRNA Name | AT102202 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | cell line (HepG2) |
| Expression Pattern | up-regulated |
| Function Description | In particular, the lncRNA AT102202 and its potential targets mRNA-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) were identified. Using a real-time polymerase chain reaction technique, we confirmed that EGCG down-regulated mRNA expression level of the HMGCR and up-regulated expression of AT102202. After AT102202 knockdown in HepG2, we observed that the level of HMGCR expression was significantly increased relative to the scrambled small interfering RNA control. |
| Pubmed ID | 25563320 |
| Year | 2015 |
| Title | Long non-coding RNAs expression profile in HepG2 cells reveals the potential role of long non-coding RNAs in the cholesterol metabolism. |
External Links
| Links for AT102202 | GenBank HGNC NONCODE |
| Links for hepatoblastoma | OMIM COSMIC |