Basic Information
| LncRNA/CircRNA Name | LSINCT5 |
| Synonyms | NA |
| Region | GRCh38_5:2712591-2715237 |
| Ensemble | |
| Refseq | NR_145480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, luciferase reporter assay, ChIP |
| Sample | gastric cancer tissues, cell lines (MGC803, BGC823, MKN45, AGS, SGC7901, GES-1) |
| Expression Pattern | up-regulated |
| Function Description | LSINCT5 was significantly over-expressed in metastatic GC tissues. Forced LSINCT5 expression promoted cell migration and invasion, LSINCT5 overexpression was found to play an important role in the epithelial-to-mesenchymal transition. |
| Pubmed ID | 30127643 |
| Year | 2018 |
| Title | E2F1 induces LSINCT5 transcriptional activity and promotes gastric cancer progression by affecting the epithelial-mesenchymal transition. |
External Links
| Links for LSINCT5 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |