Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | malignant melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | cell lines (A375 and HEMa-LP) |
| Expression Pattern | up-regulated |
| Function Description | It was identified that lncRNA activated by transforming growth factor-? (lncRNA-ATB) was upregulated in MM tissues and cells compared with benign nevus cells and human melanocytes. Furthermore, lncRNA-ATB promoted the cell proliferation, cell migration, and cell invasion of MM cells in vitro, and tumor growth in vivo. It was additionally identified that lncRNA-ATB attenuated cell cycle arrest and inhibited cellular apoptosis in MM cells. Finally, it was demonstrated that lncRNA-ATB functions as a competing endogenous RNA (ceRNA) to enhance Yes associated protein 1 expression by competitively sponging microRNA miR-590-5p in MM cells. In conclusion, the present study revealed the expression and roles of lncRNA-ATB in MM, and indicated that lncRNA-ATB functions as a ceRNA to promote MM proliferation and invasion by sponging miR-590-5p. |
| Pubmed ID | 29956757 |
| Year | 2018 |
| Title | lncRNA-ATB Functions as a Competing Endogenous RNA to Promote YAP1 by Sponging miR-590-5p in Malignant Melanoma |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for malignant melanoma | OMIM COSMIC |