Basic Information
| LncRNA/CircRNA Name | LSINCT5 |
| Synonyms | NA |
| Region | GRCh38_5:2712591-2715237 |
| Ensemble | NA |
| Refseq | NR_145480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RIP, Microarray, Western blot, etc. |
| Sample | All the lung cancer cell lines (WI-38, A549, H1299, 95D, 95C, H838) |
| Expression Pattern | up-regulated |
| Function Description | In conclusion, our current work has revealed that lncRNA LSINCT5 serves as a novel oncogenic factor which is critically involved in NSCLC progression. LSINCT5 can enhance malignant phenotypes of lung cancer both in vitro and in vivo. LSINCT5 contributes to NSCLC tumorigenesis partially by physical interaction with and stabilizing HMGA2. Kaplan-Meier survival curves for patients with NSCLC. P < 0.01 by log-rank test. |
| Pubmed ID | 29883241 |
| Year | 2018 |
| Title | The long non-coding RNA LSINCT5 promotes malignancy in non-small cell lung cancerby stabilizing HMGA2. |
External Links
| Links for LSINCT5 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |