Basic Information
| LncRNA/CircRNA Name | LUADT1 |
| Synonyms | NA |
| Region | GRCh38_6:147158925-147180992 |
| Ensemble | ENSG00000196634 |
| Refseq | NR_132442 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | melanoma and nontumor tissues, cell lines(A375 and SK-MEL-3) |
| Expression Pattern | up-regulated |
| Function Description | We found that LUADT1 was upregulated in melanoma and high levels of LUADT1 predicted poor survival. RNA interaction prediction showed that LUADT1 can form base pairing with miR-28-5p. In melanoma cells, LUADT1 overexpression mediated the upregulated Ras-related protein Rap-1b (RAP1B). Cell proliferation assay showed that LUADT1 and RAP1B overexpression mediated the increased proliferation rate of melanoma cells. In addition, miR-28-5p overexpression played opposite roles attenuating the effects of LUADT1 overexpression on both RAP1B expression and cancer cell proliferation. |
| Pubmed ID | 32191497 |
| Year | 2020 |
| Title | Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B |
External Links
| Links for LUADT1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |