Basic Information
| LncRNA/CircRNA Name | LUCAT1 |
| Synonyms | NA |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Oxaliplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RT-PCR, RNA-seq |
| Sample | cell lines(HEK-293??, HCT-116, RKO, and LoVo),colorectal cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | LUCAT1 inhibits DNA damage and apoptosis of CRC cells.LUCAT1 interacts with PTBP1 in CRC cells.LUCAT1 regulates mRNA alternative splicing through its association with PTBP1 in CRC cells.High expression of LUCAT1 confers drug resistance to CRC cells.CRC patients with high LUCAT1 have a worse prognosis and poorly respond to chemotherapy. |
| Pubmed ID | 31964396 |
| Year | 2020 |
| Title | Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response |
External Links
| Links for LUCAT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |