Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | Double-luciferase reporter assay, RT-qPCR, Western blotting analysis |
| Sample | human NCI-H226, human normal bronchial epithelial cells (HBE), BEAS-2B, SK-MES-1, and EBC-1 cell lines |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-ATB expression also markedly increases in LSC tissues and cell lines in comparison to the adjacent normal tissues and normal lung epithelial cells, respectively. Functional experiments indicate that lncRNA-ATB overexpression improves the proliferative, migratory, and invasive capabilities of normal lung epithelial cells compared with control group.lncRNA-ATB overexpression promotes the epithelial-mesenchymal transition process. |
| Pubmed ID | 31934791 |
| Year | 2020 |
| Title | LncRNA-ATB Promotes Lung Squamous Carcinoma Cell Proliferation, Migration, and Invasion by Targeting microRNA-590-5p/NF90 Axis |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |