Basic Information
| LncRNA/CircRNA Name | LUCAT1 |
| Synonyms | LUCAT1, SCAL1 |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP, in vitro knockdown etc. |
| Sample | cell lines (KYSE-30, TE-2, HCE-4, HCE-7), ESCC tissues |
| Expression Pattern | up-regulated |
| Function Description | LUCAT1 knockdown reduced cell proliferation,induced apoptosis,and upregulated tumor-suppressor genes by reducing DNA methylation in KYSE-30-cells. Moreover,LUCAT1 siRNA reduced DNA methyltransferase 1 (DNMT1) protein levels without affecting transcription. LUCAT1 regulates the stability of DNMT1 and inhibits the expression of tumor suppressors through DNA methylation, leading to the formation and metastasis of ESCC. |
| Pubmed ID | 29247823 |
| Year | 2018 |
| Title | The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma. |
External Links
| Links for LUCAT1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |