Basic Information
| LncRNA/CircRNA Name | LUNAR1 |
| Synonyms | LUNAR1 |
| Region | GRCh38_15:99014704-99031050 |
| Ensemble | NA |
| Refseq | NR_126487 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | T cell acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | We have shown that one specific Notch-regulated lncRNA, LUNAR1, is required for efficient T-ALL growth in vitro and in vivo due to its ability to enhance IGF1R mRNA expression and sustain IGF1 signaling. |
| Pubmed ID | 25083870 |
| Year | 2014 |
| Title | Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. |
External Links
| Links for LUNAR1 | GenBank HGNC NONCODE |
| Links for T cell acute lymphoblastic leukemia | OMIM COSMIC |