Basic Information
| LncRNA/CircRNA Name | MACC1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:20141916-20153531 |
| Ensemble | ENSG00000228598 |
| Refseq | NR_046756 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | HCC and adjacent paraffin-embedded tissue, cell lines(SMMC7721,HepG2, Hep3B, Bel-7402, Huh7, L02) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA MACC1-AS1 expression is significantly upregulated in HCC tissues and cells.MACC1-AS1 positively regulated the expression of stemness master regulators and inhibited spheroid-forming ability and ALDH1 activity. Furthermore, MACC1-AS1 promoted the stemness of HCC cells by antagonizing microRNA (miR)-145 activity. Overexpression of miR-145 also attenuated HCC cell stemness. |
| Pubmed ID | 32339066 |
| Year | 2020 |
| Title | Long noncoding RNA MACC1-AS1 promotes the stemness of hepatocellular carcinoma cells by antagonizing miR-145. |
External Links
| Links for MACC1-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |