Basic Information
| LncRNA/CircRNA Name | MACC1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:20141916-20153531 |
| Ensemble | ENSG00000228598 |
| Refseq | NR_046756 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical squamous cell carcinoma |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot etc |
| Sample | CSCC tissues,cell lines(SiHa) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of MACC1-AS1 is affected by clinical stage, but not by HPV infection status.MACC1-AS1 overexpression led to upregulation of CDK6, while miR-34a overexpression had the opposite effect and reduced the effects of MACC1-AS1 overexpression in co-transfected cells. Cell cycle and proliferation analyses demonstrated that MACC1-AS1 and CDK6 promoted cell cycle progression and cell proliferation. |
| Pubmed ID | 32194733 |
| Year | 2020 |
| Title | Long noncoding RNA MACC1-AS1 is a potential sponge of microRNA-34a in cervical squamous cell carcinoma and upregulates cyclin-dependent kinase 6 |
External Links
| Links for MACC1-AS1 | GenBank HGNC NONCODE |
| Links for cervical squamous cell carcinoma | OMIM COSMIC |