Basic Information
| LncRNA/CircRNA Name | MACC1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:20141916-20153531 |
| Ensemble | ENSG00000228598 |
| Refseq | NR_046756 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | RNA-seq, Microarray, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNA immunoprecipitation |
| Sample | PC cell lines BxPC-3, PANC-1, MIA PaCa-2, KP-2, AsPC-1, and Capan-1, human primary PC tissues, the paired surrounding noncancerous tissues, human primary PC tissues, the paired surrounding noncancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | The upregulation of MACC1-AS1 in PC was further confirmed in two expanded PC cohorts, which showed that MACC1-AS1 expression was upregulated in those PC patients with poor survival. Functionally, knockdown of MACC1-AS1 inhibited the proliferation as well as metastasis of PC cells. Meanwhile, MACC1-AS1 upregulated the expression of PAX8 protein, which promoted aerobic glycolysis and activated NOTCH1 signaling. Additionally, PAX8 was upregulated in PC tissues, which was correlated with the expression of MACC1-AS1 and the overall survival of PC patients. |
| Pubmed ID | 31391063 |
| Year | 2019 |
| Title | Long non-coding RNA MACC1-AS1 promoted pancreatic carcinoma progression through activation of PAX8/ NOTCH1 signaling pathway |
External Links
| Links for MACC1-AS1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |