Basic Information
| LncRNA/CircRNA Name | MAFG-AS1 |
| Synonyms | NA |
| Region | GRCh38_17:81927829-81930753 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay etc. |
| Sample | breast cancer and normal tissues ,breast carcinoma cells (MDA-MB-231, HCC1937, MCF-7, and MDA-MB-468) and normal epithelial breast cell line, MCF-10A |
| Expression Pattern | up-regulated |
| Function Description | The level of lncRNA MAFG-AS1 is higher in breast carcinoma, and the aggressive phenotypes of breast carcinoma cell are enhanced by MAFG-AS1 transfection.MAFG-AS1 overexpression reduces the expression of miR-339-5p and miR-339-5p is the target of MAFG-AS1 in breast carcinoma.MMP15 is the functional regulated gene of miR-339-5p in breast carcinoma. The aggressiveness of breast carcinoma induced by lncRNA MAFG-AS1 is weakened by the miR-339-5p.Finally, the development of breast carcinoma cell is enhanced by MAFG-AS1 in vivo. |
| Pubmed ID | 31002134 |
| Year | 2019 |
| Title | LncRNA MAFG-AS1 Promotes the Aggressiveness of Breast Carcinoma Through Regulating miR-339-5p/MMP15 |
External Links
| Links for MAFG-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |