Basic Information
| LncRNA/CircRNA Name | MAFG-AS1 |
| Synonyms | MAFG-DT |
| Region | GRCh38_17:81927829-81930753 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | CRC tissues and cell lines (HCT-116, HT29, SW480, and LoVo) |
| Expression Pattern | up-regulated |
| Function Description | Both the low-expression of miR-147b expression and the advanced tumor stage were independent factor for poor survival probability. Furthermore, overexpression of MAFG-AS1 promoted cell proliferation, cell cycle progression, and invasion, and inhibited apoptosis, while transduction of miR-147b partially reversed the effect of MAFG-AS1 on cellular processes. Consistently, stable over-expression of MAFG-AS1 contributed to the growth of colon cancer cell xenografts in vivo. NDUFA4 was identified as a direct target of miR-147b and knockdown of NDUFA4 abolished the oncogenic role of miR-147b inhibitor. Besides, MAFG-AS1 contributed to cell glycolysis by sponging miR-147b and activation of NDUFA4, causing an upregulation of PDK1, PFK1 and PKM2. |
| Pubmed ID | 30348529 |
| Year | 2018 |
| Title | LncRNA MAFG-AS1 Promotes the Progression of Colorectal Cancer by Sponging miR-147b and Activation of NDUFA4 |
External Links
| Links for MAFG-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |