Basic Information
| LncRNA/CircRNA Name | MAFG-AS1 |
| Synonyms | NA |
| Region | GRCh38_17:81927829-81930753 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | LUAD cell lines H1650, PC-9, A549 and Calu-3, and normal lung cell line HLF-a |
| Expression Pattern | up-regulated |
| Function Description | silencing of MAFG-AS1 suppressed cell proliferation but induced cell apoptosis. RNA FISH staining showing the cytoplasmic localization of MAFG-AS1 in LUAD cells. Mechanism detection revealed that MAFG-AS1 served as a molecular sponge of miR-744-5p to upregulate its nearby gene MAF bZIP transcription factor G (MAFG) in LUAD cells. Functionally, MAFG overexpression attenuated the cellular processes mediated by MAFG-AS1 knockdown. |
| Pubmed ID | 31211984 |
| Year | 2019 |
| Title | LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis |
External Links
| Links for MAFG-AS1 | GenBank HGNC NONCODE |
| Links for Lung adenocarcinoma | OMIM COSMIC |