Search Result

Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	epithelial ovarian cancer
ICD-0-3	C56.9
Methods	Microarray , qRT-PCR , Western blot , in vitro knockdown etc.
Sample	EOC and nonmalignant ovarian tissues ,EOC cell lines(ES-2, HEY, HO-8910, OVCAR-3 and SKOV3) ,normal human ovarian surface epithelium cell line HOSEpiC
Expression Pattern	down-regulated
Function Description	MAGI1-IT1 expression was found to be significantly decreased in overexpressing miR-200a EOC cells.MAGI1-IT1 expression was remarkably increased in metastatic EOC tissues, and high MAGI1-IT1 was dramatically associated with EOC FIGO III-IV stage; MAGI1-IT1 might be related to EOC dissemination via epithelial-mesenchymal transition (EMT).Upregulation of MAGI1-IT1 can remarkably facilitate EOC EMT phenotype, cells migration and invasion ability and intraperitoneal metastasis in nude mice, while downregulation of MAGI1-IT1 led to the opposite effect in vitro.MAGI1-IT1 was validated to promote EOC metastasis through upregulation of ZEB1 and ZEB2 by competitively binding miR-200a, and the restrictive effects of MAGI1-IT1 depletion on EOC metastasis could be reversed by inhibition of miR-200a and upregulation of ZEB1 and ZEB2.
Pubmed ID	31122127
Year	2019
Title	Long Noncoding RNA MAGI1-IT1 Promoted Invasion and Metastasis of Epithelial Ovarian Cancer via the miR-200a/ZEB Axis

External Links