Basic Information
| LncRNA/CircRNA Name | MAGI2-AS3 |
| Synonyms | NA |
| Region | GRCh38_7:79452877-79471208 |
| Ensemble | ENSG00000234456 |
| Refseq | NR_038343 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | NSCLC plasma |
| Expression Pattern | down-regulated |
| Function Description | The levels of MAGI2-AS3 and ZFAS1 in both plasma and platelets of NSCLC patients were significantly downregulated than those in healthy controls. A positive correlation of long noncoding RNA expression was observed between platelets and plasma. By ROC analysis, we found that molecular interrogation of MAGI2-AS3 and ZFAS1 in TEPs and plasma can offer valuable diagnostic performance for NSCLC patients. Clinicopathologic characteristic analysis further revealed that MAGI2-AS3 level significantly correlated with tumor-node-metastasis (TNM) stage , lymph-node metastasis, and distant metastasis. |
| Pubmed ID | 29922089 |
| Year | 2018 |
| Title | LncRNAs and EGFRvIII Sequestered in TEPs Enable Blood-Based NSCLC Diagnosis |
External Links
| Links for MAGI2-AS3 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |