Basic Information
| LncRNA/CircRNA Name | MAGI2-AS3 |
| Synonyms | NA |
| Region | GRCh38_7:79452877-79471208 |
| Ensemble | ENSG00000234456 |
| Refseq | NR_038343 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot |
| Sample | tissue samples,H23 (ATCC) human NSCLC cell line |
| Expression Pattern | down-regulated |
| Function Description | MAGI2-AS3 and suppressor of cytokine signaling 1 (SOCS-1) were both downregulated in NSCLC.MAGI2-AS3 overexpression mediated the upregulated, while miR-155 expression mediated the downregulated SOCS-1 overexpression. RNA binding analysis showed that MAGI2-AS3 may be a sponge of miR-155. Cell proliferation revealed decreased cell proliferation rate of NSCLC cells after MAGI2-AS3 and SOCS-1 overexpression. |
| Pubmed ID | 31910343 |
| Year | 2020 |
| Title | LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 by Sponging miR-155 in Non-Small Cell Lung Cancer |
External Links
| Links for MAGI2-AS3 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |