Basic Information
| LncRNA/CircRNA Name | MAGI2-AS3 |
| Synonyms | NA |
| Region | GRCh38_7:79452877-79471208 |
| Ensemble | ENSG00000234456 |
| Refseq | NR_038343 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical squamous cell carcinoma |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot |
| Sample | CSCC tissues,C-33A human CSCC cell line |
| Expression Pattern | up-regulated |
| Function Description | CDK6 and MAGI2-AS3 were both up-regulated in CSCC and positively correlated with each other.High levels of MAGI2-AS3 were associated with the poor survival of CSCC patients. In CSCC cells, MAGI2-AS3 over-expression up-regulated CDK6, while MAGI2-AS3 siRNA down-regulated CDK6. In CCK-8 assay, MAGI2-AS3 and CDK6 over-expression led to increased proliferation rate of CSCC cells by reducing CDK6 levels. |
| Pubmed ID | 31832086 |
| Year | 2019 |
| Title | LncRNA MAGI2-AS3 Is Involved in Cervical Squamous Cell Carcinoma Development Through CDK6 Up-Regulation |
External Links
| Links for MAGI2-AS3 | GenBank HGNC NONCODE |
| Links for cervical squamous cell carcinoma | OMIM COSMIC |