Basic Information
| LncRNA/CircRNA Name | MAGI2-AS3 |
| Synonyms | NA |
| Region | GRCh38_7:79452877-79471208 |
| Ensemble | ENSG00000234456 |
| Refseq | NR_038343 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF-7 and MCF-10A) |
| Expression Pattern | down-regulated |
| Function Description | Our results showed MAGI2-AS3 to be down-regulated in breast cancer tissues compared to normal adjacent tissues. Moreover, MAGI2-AS3 markedly inhibited breast cancer cell growth and increased expression of Fas and Fas ligand (FasL). In conclusion, our data suggest that MAGI2-AS3 expression is decreased in breast cancer and that MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. |
| Pubmed ID | 29679339 |
| Year | 2018 |
| Title | Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway. |
External Links
| Links for MAGI2-AS3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |