Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Western blot |
| Sample | esophageal cancer cell lines(KYSE30, OE21, EC109 and TE-1) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was significantly up-regulated in all EC cell lines compared with the normal cells. Silencing MALAT1 using shRNA could significantly inhibit cell viability, invasion , and migration of both TE-1 and EC109 cells. Meanwhile, expression of Ezh2, Notch1, Hes1, MMP-9, and Vimentin was significantly decreased and expression of E-cadherin was significantly increased when cells were transfected with sh-MALAT1 compared with the nontransfected cells. However, when cells were cotransfected with both sh-MALAT1 and pcDNA3.1-Ezh2, the protein expression changes induced by sh-MALAT1 were recovered. MALAT1 could affect EMT and metastasis of EC cells through Ezh2-Notch1 signaling pathway. |
| Pubmed ID | 29916899 |
| Year | 2018 |
| Title | LncRNA MALAT1 Promotes Epithelial-To-Mesenchymal Transition of Esophageal Cancer Through Ezh2-Notch1 Signaling Pathway |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |