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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating	2
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	anaplastic thyroid cancer
ICD-0-3	C73
Methods	qPCR, other
Sample	anaplastic thyroid cancer cell lines (TPC-1 and THJ-16T)
Expression Pattern	up-regulated
Function Description	Additionally, the cells were examined for lncRNA expression after 6 days of treatment by RT-qPCR revealing a significant upregulation in 3 lncRNAs(MALAT1, PVT1 and linc-ROR) studied. The EMT exosomes transferred the lncRNA MALAT1 and EMT effectors SLUG and SOX2; however, EMT was not induced in this model. The exosomes from the CSC model also transferred the lncRNA MALAT1 and the transcription factors SLUG and SOX2 but additionally transferred linc-ROR and induced EMT in the normal thyroid cells. Preliminary siRNA studies directed towards linc-ROR reduced invasion. We hypothesize that CSC exosomes transfer lncRNAs, importantly linc-ROR, to induce EMT and inculcate the local tumor microenvironment and the distant metastatic niche. Therapies directed towards CSCs, their exosomes and/or the lncRNAs they carry may reduce a tumor's metastatic capacity.Both the EMT and the CSC exosomes transferred MALAT1, SOX2 and SLUG to their respective na?ve cells and increased proliferation in those cells.
Pubmed ID	29967342
Year	2018
Title	Thyroid Cancer Stem-Like Cell Exosomes: Regulation of EMT via Transfer of lncRNAs

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