Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal and hypopharyngeal Carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc |
| Sample | laryngeal and hypopharyngeal cancer tissues,cell lines(Hep-2 and FaDu ) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was up-regulated in laryngeal and hypopharyngeal cancer tissues. MALAT1 down-regulation induced the increased apoptosis of both cell lines and suppressed cells??proliferation. Cells were arrested in G1/G2 phase and cells of S phase were significantly decreased. |
| Pubmed ID | 31792655 |
| Year | 2019 |
| Title | Blocking Long Noncoding RNA MALAT1 Restrained the Development of Laryngeal and Hypopharyngeal Carcinoma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for laryngeal and hypopharyngeal Carcinoma | OMIM COSMIC |