Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | metastasis-associated lung adenocarcinoma transcript 1 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qRT-PCR, Western blot, Dual luciferase reporter assay |
| Sample | Serum samples,cell lines (NCI-H929 and OPM-2,nPCs) |
| Expression Pattern | up-regulated |
| Function Description | The up-regulation of MALAT1 and the down-regulation of miR-1271-5p were found in MM serums and cells. MALAT1 knockdown suppressed cell viability, invasion, and glycolysis while expedited cell apoptosis in MM cells. MALAT1 directly targeted miR-1271-5p and miR-1271-5p depression reverted the effects of MALAT1 knockdown on MM cells. |
| Pubmed ID | 31953613 |
| Year | 2020 |
| Title | Long Non-Coding RNA MALAT1 Facilitates the Tumorigenesis, Invasion and Glycolysis of Multiple Myeloma via miR-1271-5p/SOX13 Axis |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for multiple myeloma | OMIM COSMIC |