Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin,5-fluorouracil,Paclitaxel,vincristine | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | RT-PCR, Western blotting |
| Sample | tumor tissues,laryngeal cancer cell lines (ie TU686, TU177, AMC-HN-8, and LSC-1) and the normal human bronchial epithelial cells (NHBEC) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 expression was higher in LSCC tissues than in adjacent normal tissues, and LSCC patients who carried highly expressed MALAT1 demonstrated poorer 5-year survival than ones with low MALAT1 expression.LncRNA MALAT1 counted in triggering tolerance of LSCC against chemo-drugs by boosting metastasis and depressing apoptosis of tumor cells. |
| Pubmed ID | 31837057 |
| Year | 2020 |
| Title | The Implication of LncRNA MALAT1 in Promoting Chemo-Resistance of Laryngeal Squamous Cell Carcinoma Cells |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |