Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | ESCC cell lines( Eca-109 and TE-1),normal human esophageal epithelial cells (HEEC) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 expression was remarkably increased in ESCC cells compared to normal human esophageal epithelial cells.In addition, knockdown of MALAT1 attenuated the stemness of ESCC cells, as evidenced by a decrease in spheroid formation capacity, stemness marker expression and aldehyde dehydrogenase 1 activity.MALAT1 knockdown decreased the migration ability of ESCC cells.Notably, knockdown of MALAT1 enhanced the radiosensitivity and chemosensitivity of ESCC cells.MALAT1 binds directly to Yes-associated protein (YAP), thereby enhancing YAP protein expression and increasing YAP transcriptional activity. Overexpression of YAP partially rescued the effect of MALAT1 knockdown on stemness and radiosensitivity of ESCC cells. |
| Pubmed ID | 31116509 |
| Year | 2019 |
| Title | Long Noncoding RNA MALAT1 Promotes the Stemness of Esophageal Squamous Cell Carcinoma by Enhancing YAP Transcriptional Activity |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |