Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | infantile hemangioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | infantile skin hemangioma in the proliferative stage and involuting stage, and normal subcutaneous tissues ,human hemangioma endothelial cells (HemECs) |
| Expression Pattern | down-regulated |
| Function Description | In IH tissues, MALAT1 and MEKK3 were overexpressed while miR-424 was down-regulated.Silencing MALAT1 or overexpression of miR-424 significantly inhibited the IH cell proliferation, migration and tube formation, but promoted the cell apoptosis.Knockdown of MALAT1 suppressed the expression of MEKK3 and inactivated the IKK/NF-?B pathway by sponging miR-424.Overexpression of MEKK3 in HemEcs reversed the impact of knockdown of MALAT1 and overexpression of miR-424 on the cell proliferation, apoptosis, migration, invasion and tube formation rate.Silencing MALAT1 significantly inhibited the tumor growth in vivo and Ki-67 in the tumor tissues was also significantly suppressed. |
| Pubmed ID | 31610202 |
| Year | 2019 |
| Title | LncRNA-MALAT1 Promotes Tumorogenesis of Infantile Hemangioma by Competitively Binding miR-424 to Stimulate MEKK3/NF-?B Pathway |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for infantile hemangioma | OMIM COSMIC |