Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | peripheral blood mononuclear cells (PBMCs), CD8+ cytotoxic T lymphocyte (CTL) | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | blood |
| Expression Pattern | down-regulated |
| Function Description | MALAT1 levels were decreased in PBMCs from lung cancer patients. In this study, we observed an increased proportion of MDSCs and elevated levels of the related molecule arginase-1 (ARG-1) in peripheral blood mononuclear cells (PBMCs) obtained from lung cancer patients. The proportion of CD8+ cytotoxic T lymphocyte (CTL) was significantly decreased in PBMCs from lung cancer patients. |
| Pubmed ID | 30026840 |
| Year | 2018 |
| Title | LncRNA MALAT1 Negatively Regulates MDSCs in Patients With Lung Cancer. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |