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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	bladder cancer
ICD-0-3	C67
Methods	qPCR, RNAi, Western blot, Luciferase reporter gene assay, other
Sample	BC tissues and cell lines (HT-1376, RT112,253J and T24)
Expression Pattern	up-regulated
Function Description	The expression levels of MALAT1 were higher in stage III-IV BC tissues when compared with that in stage I-II tissues. Furthermore, knockdown of MALAT1 significantly inhibited BC cell proliferation and migration by targeting microRNA (miR)-34a. The expression levels of miR-34a were significantly decreased in BC tissues and cell lines compared with that of adjacent non-tumour tissues and SV-HUC-1 cells. In addition, the expression of miR-34a was inversely correlated with the expression of MALAT1 in BC tissues. The present study revealed that cyclin D1 (CCND1) was identified as a target gene of miR-34a, and its expression was negatively mediated by miR-34a in BC cells. Notably, the upregulation of CCND1 impaired the effect of MALAT1 inhibition on BC cell proliferation and migration. In addition, the expression levels of CCND1 were significantly increased in BC tissues and cell lines.
Pubmed ID	30387807
Year	2019
Title	Knockdown of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 inhibits the proliferation and migration of bladder cancer cells by modulating the microRNA-34a/cyclin D1 axis.

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