Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | Dihydromyricetin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cutaneous squamous cell carcinoma |
| ICD-0-3 | C49 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, other |
| Sample | CSCC tissues and cell lines (A431) |
| Expression Pattern | down-regulated |
| Function Description | Importantly, DHM decreased lncRNA MALAT1 expression and MALAT1 overexpression abrogated the effects of DHM on TFEB-dependent autophagy both in vitro and in vivo. Taken together, DHM induces CSCC cell death via inducing excessive autophagy, which is mediated through the MALAT1-TFEB pathway. Therefore, DHM may be beneficial for the development of chemotherapy for CSCC |
| Pubmed ID | 31413743 |
| Year | 2019 |
| Title | Dihydromyricetin Induced lncRNA MALAT1 - TFEB-dependent Autophagic Cell Death in Cutaneous Squamous Cell Carcinoma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for cutaneous squamous cell carcinoma | OMIM COSMIC |