Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NEAT2 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Chronic lymphocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | peripheral blood |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 expression level was up-regulated in the CLL group compared to healthy controls (P=0.008). Del13q14, followed by Del11q22, were the most prevalent cytogenetic abnormalities. We found no association between the FISH results and MALAT1 expression in patients. |
| Pubmed ID | 30588470 |
| Year | 2018 |
| Title | Altered expression of MALAT1 lncRNA in chronic lymphocytic leukemia patients, correlation with cytogenetic findings |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for Chronic lymphocytic leukemia | OMIM COSMIC |