Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | T and NK cell lymphoma |
| ICD-0-3 | C86.0 |
| Methods | qPCR, Western blot, RNAi |
| Sample | T and NK cell lymphoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Among the tested lncRNAs, MALAT1 was most highly expressed in clinical samples and cell lines. High expression of MALAT1 as well as BMI1 was related to poor prognosis in patients with mature T cell lymphoma. In the tissue samples, BMI1 expression showed a positive correlation with EZH2, SUZ12, H3K27me3, and MALAT1. Multiple linear regression analysis showed that BMI1 expression was independently associated with H3K27me3. |
| Pubmed ID | 28412742 |
| Year | 2017 |
| Title | Association of the long non-coding RNA MALAT1 with the polycomb repressive complex pathway in T and NK cell lymphoma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for T and NK cell lymphoma | OMIM COSMIC |