Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | mantle cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, RIP etc. |
| Sample | blood, cell lines (Mino and Jeko-1) |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression of MALAT1 was elevated in human MCL tumors and cell lines as compared to normal controls, and the elevated levels of MALAT1 correlated with higher MCL international prognostic index (MIPI) and reduced overall survival. MCL with knockdown of MALAT1 showed impaired cell proliferation, facilitated apoptosis and produced fewer clonogenic foci. The increased expression of p21 and p27 upon MALAT1 knockdown was regulated by enhancer of zeste homolog 2 (EZH2). Moreover, decreased phosphorylation of EZH2 at T350 attenuated the binding to MALAT1. |
| Pubmed ID | 27998273 |
| Year | 2016 |
| Title | LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for mantle cell lymphoma | OMIM COSMIC |