Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | urothelial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | cell lines (T24, 5737) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was upregulated in bladder urothelial carcinoma compared with matched normal urothelium. The MALAT1 expression levels were greater in high-grade carcinomas than in low-grade carcinoma. The MALAT1 expression levels were greater in invasive carcinoma than in noninvasive carcinoma. MALAT1 plays an oncogenic role in urothelial carcinoma of the bladder. |
| Pubmed ID | 23153939 |
| Year | 2013 |
| Title | Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for urothelial cancer | OMIM COSMIC |