Basic Information
| LncRNA/CircRNA Name | AWPPH |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | GC tissues, GC cell lines (including HGC-27, BGC-823, SGC-7901 and MKN-45) and normal human gastric epithelial cell line GES-1 |
| Expression Pattern | down-regulated |
| Function Description | LncRNA AWPPH was remarkably downregulated in GC and associated with metastasis. CCK8 and transwell assays proved that AWPPH inhibited cell proliferation and invasion in GC cells. MiR-203a was a predicted and further verifed target of AWPPH. DKK2 was verifed as a direct target of miR-203a. Upregulation of miR-203a attenuated the repressive efects of AWPPH on GC cell proliferation and invasion. AWPPH inhibited GC cell proliferation and invasion via miR-203a/DKK2 axis. This fnding might provide new insight for the potential therapeutic strategies for GC in the future. |
| Pubmed ID | 31489578 |
| Year | 2019 |
| Title | Up-regulation of long non-coding RNA AWPPH inhibits proliferation and invasion of gastric cancer cells via miR-203a/DKK2 axis |
External Links
| Links for AWPPH | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |