Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | medullary thyroid cancer |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR etc. |
| Sample | MTCs tissue, cell lines (MZ-CRC-1, HT-ORI-3) |
| Expression Pattern | up-regulated |
| Function Description | There is increased expression of miR-21 and MALAT1 in MTCs. This study also showed an in vitro pro-oncogenic effect of MALAT1 and miR-21 in MTCs. The results suggest that overexpression of miR-21 and MALAT1 may regulate MTC progression. |
| Pubmed ID | 29107050 |
| Year | 2017 |
| Title | MicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for medullary thyroid cancer | OMIM COSMIC |