Basic Information
| LncRNA/CircRNA Name | AWPPH |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP, ChIP etc. |
| Sample | HCC tissues, cell lines (QSG-7701, SMMC-7721, HCCLM3, Huh7, HepG2, QSG-7701 and SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | High AWPPH expression is an independent prognostic factor for poor recurrence-free and overall survival. AWPPH promotes HCC cell proliferation and migration in vitro, and tumor growth and metastasis in vivo. AWPPH interacts with YBX1, promotes YBX1-mediated activation of SNAIL1 translation, and upregulates SNAIL1 expression.To identify lncRNAs involved in the progression and prognosis of HCC, we analyzed online-available data sets, including GSE54238 (lncRNAs microarray data of 30 noncancerous hepatic tissues and 23 HCC tissues) and GSE40144 (lncRNAs microarray data of 59 HCC tissues with disease-free survival and overall survival information). |
| Pubmed ID | 28428004 |
| Year | 2017 |
| Title | Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker. |
External Links
| Links for AWPPH | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |