Basic Information
LncRNA/CircRNA Name | MALAT1 |
Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
Region | GRCh38_11:65497688-65506516 |
Ensemble | ENSG00000251562 |
Refseq | NR_002819 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | pancreatic ductal adenocarcinoma |
ICD-0-3 | C25.3 |
Methods | qPCR, Western blot, RIP, RNA pull-down assay etc. |
Sample | cell lines (Bxpc-3, Panc-1) |
Expression Pattern | up-regulated |
Function Description | In this study, MALAT1 was found to be highly expressed in PDAC tissues, and elevated expression was associated with poorer prognoses. In addition, MALAT1 was positively linearly correlated with the expression of LC3B mRNA. Furthermore, several molecules involved in cellular autophagic flux were modulated following the downregulation of MALAT1, including LC3, P62, and LAMP-2. Mechanistically, we found that MALAT1 interacted with RNA binding protein HuR, and silencing of MALAT1 greatly enhanced the posttranscriptional regulation of TIA-1 and had further effects on inhibiting autophagy. MALAT1 was speculated to regulate tumorigenesis via HuR-TIA-1-mediated autophagic activation. |
Pubmed ID | 27371730 |
Year | 2016 |
Title | Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy. |
External Links
Links for MALAT1 | GenBank HGNC NONCODE |
Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |