Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | TSCC tissues, cell lines (SCC-9 and CAL-27) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA MALAT1 was upregulated in TSCC tissues and correlated with cervical lymph node metastasis in TSCC patients. Moreover, MALAT1 induced cell migration, invasion, EMT, and inhibited apoptosis by modulating Wnt/B-catenin signaling pathway. Finally, inhibiting Wnt/B-catenin signaling pathway attenuated the effect of exogenous MALAT1. |
| Pubmed ID | 27353727 |
| Year | 2016 |
| Title | MALAT1 induces tongue cancer cells' EMT and inhibits apoptosis through Wnt/B-catenin signaling pathway. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for tongue squamous cell carcinoma | OMIM COSMIC |