Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | human ovarian cell lines (OVCAR3 (adenocarcinoma), Caov3 (adenocarcinoma), SK-OV-3 (adenocarcinoma), PA-1 (teratocarcinoma), MES-OV (ovarian serous cystadenocarcinoma), UWB1.289 (ovarian carcinoma), OV-90 (malignant papillary serous adenocarcinoma), HEY-T30 (papillary cystadenocar)) |
| Expression Pattern | up-Regulated |
| Function Description | In general, results of this study indicated that lncRNA MALAT1 is a oncogene in ovarian cancer, involved in the regulation of cell viability, migration and invasion abilities of ovarian cancer cells, which achieved its biological function by regulating miR-200c expression. Therefore, lncRNA MALAT1 could be a promising prognostic biomarker and therapeutic target for ovarian cancer and its relation with miR-200c might be a starting point for future researches. LncRNAs and miRNAs have both been reported in the tumorigenesis of varied cancers, including ovarian cancer, respectively. |
| Pubmed ID | 28899458 |
| Year | 2017 |
| Title | Long Noncoding RNA MALAT1 Functions as a Sponge of MiR-200c in Ovarian Cancer. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |