Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | Microarray, qPCR, in vitro knockdown etc. |
| Sample | cell lines (SKOV3, 293T) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that MALAT1 inhibition significantly suppressed tumorigenity in vitro and in vivo. Compared with the control cells, 921 genes in the MALAT1-knockdown cells were deregulated by at least two-fold. |
| Pubmed ID | 27313681 |
| Year | 2016 |
| Title | Inhibition of the long non-coding RNA MALAT1 suppresses tumorigenicity and induces apoptosis in the human ovarian cancer SKOV3 cell line. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |