Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, ChIP, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | bladder urothelial carcinoma tissues, cell lines (T24, 5737, SV-HUC-1, HEK 293T) |
| Expression Pattern | up-regulated |
| Function Description | Hsa-miR-125b was down-regulated in bladder cancer compared with matched normal urothelium. Both SIRT7 and MALAT1 were up-regulated in bladder cancer compared with matched normal urothelium. Upregulation of hsa-miR-125b or downregulation of SIRT7 inhibited proliferation, motility and increased apoptosis. |
| Pubmed ID | 24512851 |
| Year | 2013 |
| Title | Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |