Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi |
| Sample | cell lines (MNNG/HOS) |
| Expression Pattern | differential expression |
| Function Description | MALAT1 plays an important role in OS progression by modulating the enhancers of zeste homolog 2 (EZH2).MALAT1 could inhibit the expression of E-cadherin and promote the expression of B-catenin, and tthis phenomenon might be the outcome of MALAT1-induced EZH2 activation. MALAT1 silencing using small interfering RNAs (siRNAs), the loss of E-cadherin of MNNG/HOS cells was rescued, and the abnormal expression and localization of B-catenin were corrected at the same time.The MALAT1/EZH2 axis participates in OS cell proliferation, migration, and cell survival in vitro. |
| Pubmed ID | 29290771 |
| Year | 2018 |
| Title | Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of B-catenin. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |