Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Cell transfection, Western blot, Dual luciferase reporter assay, Flow cytometry assay etc. |
| Sample | cell lines (SiHa and CaSki) |
| Expression Pattern | differential expression |
| Function Description | MiR-375 overexpression or MALAT1 siRNA partly restored E-cadherin expression and also significantly reduced N-cadherin. Following immunofluorescent staining confirmed these trends. Since EMT is an important mechanism of enhanced tumor cell invasion and metastasis, we further detected how miR-375 and MALAT1 modulate invasion capacity of SiHa cells. Transwell assay showed that both miR-375 overexpression and MALAT1 knockdown significantly reduced invasion capacity of SiHa cells. |
| Pubmed ID | 27658300 |
| Year | 2016 |
| Title | MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |