Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | Hepatocellular carcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Circulatory MALAT1 might represent a putative non-invasive prognostic biomarker indicating worse liver failure score in HCV-related HCC patients with traditional markers.Supporting our bioinformatics prediction, MALAT1 served as a competitive endogenous RNA (ceRNA)to miR-143-3p,which in turn,caused up-regulation of ZEB1 and promoted cancer growth and metastasis in Bel-7402 and HepG2 cell lines. |
| Pubmed ID | 29604585 |
| Year | 2018 |
| Title | Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |